Ortho-gynest (other name Estriol)

Common use

Estriol is primarily used to manage menopausal symptoms like hot flashes, night sweats, and vaginal atrophy. This hormone belongs to the estrogen group of medicines. Other uses include managing vaginal dryness, irritation, and inflammation in postmenopausal women, maintaining bone mineral density to prevent or treat postmenopausal osteoporosis, and relieving urinary symptoms like frequent urination, incontinence, and recurrent infections in postmenopausal women. It is also sometimes used to monitor pregnancy health and in certain high-risk pregnancies to prevent preterm birth.

Dosage and direction

The best time to take Estriol will depend on the specific medical condition being managed and your doctor's advice. Always follow your doctor's instructions regarding the timing and dosage of this medication.

Precautions

Estriol is not recommended during pregnancy or while breastfeeding. Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution is advised when using Estriol in patients with: Hypertension; Diabetes mellitus; Migraines; Endometriosis; Uterine fibroids; Hypothyroidism.

Contraindications

Estriol is contraindicated in patients with undiagnosed abnormal vaginal bleeding, active deep vein thrombosis or pulmonary embolism, a history of venous thromboembolism, known or suspected breast cancer or other estrogen-sensitive cancers, and liver disease.

Possible side effect

Side effects of Estriol: Breast tenderness or enlargement; Headache; Nausea; Fluid retention; Irregular vaginal bleeding or spotting.

Drug interaction

This medicine may interact with anticoagulants (such as warfarin and heparin), antiplatelet agents (like aspirin and clopidogrel), antidiabetic medications (including metformin and insulin), antihypertensives (such as amlodipine and lisinopril), corticosteroids (including prednisone), immunosuppressants like cyclosporine and tacrolimus, seizure medications including lamotrigine, thyroid hormones like levothyroxine, and bronchodilators such as theophylline.

Missed dose

If you miss a dose of Estriol, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the forgotten one.

Overdose

An overdose of Estriol may lead to excessively high estrogenic effects such as severe nausea, vomiting, and vaginal bleeding. If you experience these symptoms, it is crucial to seek medical assistance promptly.

Storage

Estriol cream should be kept at a room temperature (20°C - 25°C). Don't keep it in extreme heat or cold. Estriol cream needs to be stored in a dry environment to avoid the medication being harmed by moisture. When taking Estriol cream, check the expiration date and discard any expired medication.